8/17/2023 0 Comments Sensitive nerve endings![]() ![]() For the pain management, local drug delivery can focus on the specific peripheral mechanisms including transduction and transmission of nociceptive signaling to limit both peripheral and central sensitization processes. That is, to some extent, the inhibition of peripheral sensitization may prevent the subsequent central events. Pain usually starts with the activation of peripheral sensory neurons which subsequently process and convey nociceptive message to spinal cord and brain regions. Peripheral sensitization increases the release of the neurotransmitters from the peripheral endings and the terminals of the spinal cord, aggravating the neurogenic inflammation and nociception. ![]() However, there is no satisfactory therapy for the management of allodynia and hyperalgesia. The peripheral sensitization and central sensitization together produce neuropathic pain and inflammatory pain reflected as allodynia and hyperalgesia. Similar sensitization phenomenon taking place in the central nervous system is called central sensitization, which may be initially induced by peripheral sensitization. The endogenous chemicals released from the site of tissue injury or inflammation can activate and sensitize the peripheral sensory neurons, resulting in peripheral sensitization. Tissue injury may accompany the injury of peripheral nerve endings to some content. Commonly, peripheral sensitization occurs following peripheral nerve injury, tissue injury, and inflammation. Peripheral sensitization refers to reduced threshold and augmented response of the sensory nerve fibers in the peripheral to external stimulus, which is manifested as enhanced stimulus-dependent pain called primary hyperalgesia. ![]()
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